The prognosis and possible cause of severe primary lymphoedema.
Identifieur interne : 00F108 ( Main/Exploration ); précédent : 00F107; suivant : 00F109The prognosis and possible cause of severe primary lymphoedema.
Auteurs : J. H. WolfeSource :
- Annals of The Royal College of Surgeons of England [ 0035-8843 ] ; 1984.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Lymphoedème, Noeuds lymphatiques.
- étiologie : Lymphoedème.
- Adolescent, Adulte, Animaux, Enfant, Femelle, Humains, Lapins, Ligature, Lymphographie, Mâle, Pelvis, Pronostic.
English descriptors
- KwdEn :
- MESH :
- etiology : Lymphedema.
- pathology : Lymph Nodes, Lymphedema.
- Adolescent, Adult, Animals, Child, Female, Humans, Ligation, Lymphography, Male, Pelvis, Prognosis, Rabbits.
Abstract
We studied 372 patients with primary lymphoedema in order to predict the extent and severity of the disease. We found that the limits of oedema were defined early in the process and that the loss of distal lymphatics alone did not lead to severe oedema. Severe lymphoedema was associated with pelvic lymphatic 'obstruction' on lymphography and 26% of these patients eventually required surgery. Lymphography suggested that the 'obstruction' was related to lymph nodes and inguinal node biopsies were taken at the time of lymphography in 72 patients. In patients with pelvic lymphatic 'obstruction' we found a severe nodal fibrosis which was not apparent in those with distal lymphatic disease alone. This fibrosis was not related to episodes of cellulitis and since it was present in the early stages of the disease it is unlikely to be due to slow obliteration of distal lymphatics. Furthermore it could not be reproduced by ligating either afferent or efferent lymphatics of the rabbit popliteal lymph node. This suggests that severe primary lymphoedema may develop as a result of disease of the pelvic lymph nodes.
Url:
PubMed: 6742737
PubMed Central: 2492713
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001309
- to stream Pmc, to step Curation: 001308
- to stream Pmc, to step Checkpoint: 004532
- to stream PubMed, to step Corpus: 006933
- to stream PubMed, to step Curation: 006933
- to stream PubMed, to step Checkpoint: 006933
- to stream Ncbi, to step Merge: 00AC37
- to stream Ncbi, to step Curation: 00AC37
- to stream Ncbi, to step Checkpoint: 00AC37
- to stream Main, to step Merge: 00FF52
- to stream Main, to step Curation: 00F108
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The prognosis and possible cause of severe primary lymphoedema.</title><author><name sortKey="Wolfe, J H" sort="Wolfe, J H" uniqKey="Wolfe J" first="J. H." last="Wolfe">J. H. Wolfe</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">6742737</idno><idno type="pmc">2492713</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492713</idno><idno type="RBID">PMC:2492713</idno><date when="1984">1984</date><idno type="wicri:Area/Pmc/Corpus">001309</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001309</idno><idno type="wicri:Area/Pmc/Curation">001308</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001308</idno><idno type="wicri:Area/Pmc/Checkpoint">004532</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">004532</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">006933</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">006933</idno><idno type="wicri:Area/PubMed/Curation">006933</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">006933</idno><idno type="wicri:Area/PubMed/Checkpoint">006933</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">006933</idno><idno type="wicri:Area/Ncbi/Merge">00AC37</idno><idno type="wicri:Area/Ncbi/Curation">00AC37</idno><idno type="wicri:Area/Ncbi/Checkpoint">00AC37</idno><idno type="wicri:doubleKey">0035-8843:1984:Wolfe J:the:prognosis:and</idno><idno type="wicri:Area/Main/Merge">00FF52</idno><idno type="wicri:Area/Main/Curation">00F108</idno><idno type="wicri:Area/Main/Exploration">00F108</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The prognosis and possible cause of severe primary lymphoedema.</title><author><name sortKey="Wolfe, J H" sort="Wolfe, J H" uniqKey="Wolfe J" first="J. H." last="Wolfe">J. H. Wolfe</name></author></analytic><series><title level="j">Annals of The Royal College of Surgeons of England</title><idno type="ISSN">0035-8843</idno><idno type="eISSN">1478-7083</idno><imprint><date when="1984">1984</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Female</term><term>Humans</term><term>Ligation</term><term>Lymph Nodes (pathology)</term><term>Lymphedema (etiology)</term><term>Lymphedema (pathology)</term><term>Lymphography</term><term>Male</term><term>Pelvis</term><term>Prognosis</term><term>Rabbits</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Animaux</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Lapins</term><term>Ligature</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (étiologie)</term><term>Lymphographie</term><term>Mâle</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Pelvis</term><term>Pronostic</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Noeuds lymphatiques</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymph Nodes</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Female</term><term>Humans</term><term>Ligation</term><term>Lymphography</term><term>Male</term><term>Pelvis</term><term>Prognosis</term><term>Rabbits</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Animaux</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Lapins</term><term>Ligature</term><term>Lymphographie</term><term>Mâle</term><term>Pelvis</term><term>Pronostic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We studied 372 patients with primary lymphoedema in order to predict the extent and severity of the disease. We found that the limits of oedema were defined early in the process and that the loss of distal lymphatics alone did not lead to severe oedema. Severe lymphoedema was associated with pelvic lymphatic 'obstruction' on lymphography and 26% of these patients eventually required surgery. Lymphography suggested that the 'obstruction' was related to lymph nodes and inguinal node biopsies were taken at the time of lymphography in 72 patients. In patients with pelvic lymphatic 'obstruction' we found a severe nodal fibrosis which was not apparent in those with distal lymphatic disease alone. This fibrosis was not related to episodes of cellulitis and since it was present in the early stages of the disease it is unlikely to be due to slow obliteration of distal lymphatics. Furthermore it could not be reproduced by ligating either afferent or efferent lymphatics of the rabbit popliteal lymph node. This suggests that severe primary lymphoedema may develop as a result of disease of the pelvic lymph nodes.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Fig. 3</label><graphic xlink:href="annrcse01526-0030-a" xlink:role="254"></graphic></fig><fig id="F2"><label>Fig. 4</label><graphic xlink:href="annrcse01526-0030-b" xlink:role="254"></graphic></fig><fig id="F3"><label>Fig. 5</label><graphic xlink:href="annrcse01526-0032-a" xlink:role="256"></graphic></fig></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Wolfe, J H" sort="Wolfe, J H" uniqKey="Wolfe J" first="J. H." last="Wolfe">J. H. Wolfe</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00F108 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00F108 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2492713
|texte= The prognosis and possible cause of severe primary lymphoedema.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:6742737" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |